The molecular mechanisms of cellular senescence/apoptosis
Regulation of adipogenesis
Development of immunoprophylactic and immunotherapeutic drug for chronical diseases
학력
(Ph.D.) University of South Carolina, School of Medicine, USA (1991)
1993~ : Assistant, Associate, and Full Professor, Sungkyunkwan University
학술지 논문
(2019)
Anti-Inflammatory Activity of Lobaric Acid via Suppressing NF-κB/MAPK Pathways or NLRP3 Inflammasome Activation..
PLANTA MEDICA.
85,
4
(2019)
Interleukin-10 suppresses adipogenesis via Wnt5a signaling pathway in 3T3-L1 preadipocytes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.
509,
4
(2019)
Acrylamide induces adipocyte differentiation and obesity in mice..
CHEMICO-BIOLOGICAL INTERACTIONS.
298,
1
(2019)
Allicin induces beige-like adipocytes via KLF15 signal cascade..
JOURNAL OF NUTRITIONAL BIOCHEMISTRY.
64,
1
(2018)
A natural compound, aristoyagonine, is identified as a potent bromodomain inhibitor by mid-throughput screening.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.
503,
2
(2018)
Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer.
PLOS ONE.
13,
6
(2018)
Inhibitory effect of sinigrin on adipocyte differentiation in 3T3-L1 cells: Involvement of AMPK and MAPK pathways.
BIOMEDICINE & PHARMACOTHERAPY.
102,
(2018)
Intranasal Immunization With an Attenuated pep27 Mutant Provides Protection From Influenza Virus and Secondary Pneumococcal Infections.
JOURNAL OF INFECTIOUS DISEASES.
217,
4
(2017)
Inhibition of Autolysis by Lipase LipA in Streptococcus pneumoniae Sepsis.
MOLECULES AND CELLS.
40,
12
(2017)
Pneumolysin-induced autophagy contributes to inhibition of osteoblast differentiation through downregulation of Sp1 in human osteosarcoma cells.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS.
1861,
11
(2017)
Total Synthesis and Anti-inflammatory Evaluation of Penchinone A and Its Structural Analogues.
JOURNAL OF ORGANIC CHEMISTRY.
82,
21
(2017)
Effect of decreased BCAA synthesis through disruption of ilvC gene on the virulence of Streptococcus pneumoniae.
ARCHIVES OF PHARMACAL RESEARCH.
40,
8
(2017)
Identification of novel ALK2 inhibitors and their effect on cancer cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.
492,
1
(2017)
mTOR controls ChREBP transcriptional activity and pancreatic beta cell survival under diabetic stress.
JOURNAL OF CELL BIOLOGY.
216,
7
(2017)
Hepatic anti-inflammatory effect of hexane extracts of Dioscorea batatas Decne: Possible suppression of toll-like receptor 4-mediated signaling.
BIOMEDICINE & PHARMACOTHERAPY.
92,
(2017)
Sinigrin attenuates the progression of atherosclerosis in ApoE(-/-) mice fed a high-cholesterol diet potentially by inhibiting VCAM-1 expression.
CHEMICO-BIOLOGICAL INTERACTIONS.
272,
(2017)
Pneumolysin induces cellular senescence by increasing ROS production and activation of MAPK/NF-kappa B signal pathway in glial cells.
TOXICON.
129,
(2017)
Sinigrin inhibits production of inflammatory mediators by suppressing NF-kappa B/MAPK pathways or NLRP3 inflammasome activation in macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY.
45,
(2017)
Oscarellin, an Anthranilic Acid Derivative from a Philippine Sponge, Oscarella stillans, as an Inhibitor of Inflammatory Cytokines in Macrophages.
JOURNAL OF NATURAL PRODUCTS.
80,
1
(2016)
Inhibitory Effect of Methyl 2-(4 '-Methoxy-4 '-oxobutanamide) Benzoate from Jerusalem Artichoke (Helianthus tuberosus) on the Inflammatory Paracrine Loop between Macrophages and Adipocytes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.
64,
49
단행본
(2016)
면역학개론.
신일상사.
주저자
(2014)
약품미생물학 요약및 연습.
라이프사이언스.
공동
(2012)
면역학개론.
신일상사.
주저자
(2011)
최신면역학.
라이프사이언스.
공동
(2011)
약리학.
포널스.
공동
(2011)
약품미생물학.
신일상사.
공동
(2008)
면역학 개론.
신일상사.
주저자
(2007)
면역학.
라이프사이언스.
단독
(2007)
약품미생물학 연습.
신일북스.
공동
(2006)
세포사멸 관련인자 발굴과 분자 기작에 관한 이해.
영신기획.
단독
(2006)
수초염기성단백질과 수초염기성 단백질 변형펩타이드를 이용한 면역요법.
영신기획.
단독
(2006)
신종합미생물학.
신일상사.
공동
(2005)
종합미생물학.
신일상사.
공동
(2005)
면역조절제.
신일상사.
단독
(2003)
발기부전치료제.
승림문화 인쇄.
공동
(2003)
면역학강의.
자유아카데미.
단독
(2002)
2002 생명공학기술IV.
승림문화인쇄.
공동
(2001)
최신 실험 미생물학.
신일상사.
공동
(1999)
신약품미생물학.
학창사.
공동
특허/프로그램
라말린을 유효성분으로 함유하는 암의 예방및 치료용 조성물.
10-2015-0008891.
20160719.
대한민국
폴리트리카스트럼 알피넘 유래 신규 화합물 오하이오넨신 Ｆ를 함유하는 동맥경화증 예방 또는 치료용 조성물.
10-2011-0107526.
20140115.
대한민국
라말린을 함유하는 염증질환 또는 면역질환의 예방 또는 치료용 약학조성물.
10-2010-0052551.
20130723.
대한민국
신규 화합물 스테레오칼핀 Ａ를 함유하는 동맥경화증 예방 또는 치료용 조성물.
1020110108222 .
20130603.
대한민국
Jab1을 포함하는 바이러스 감염질환치료 조성물.
2005-517344.
20091211.
일본
버섯추출물의 제조방법, 그에 의해서 얻어지는 버섯추출물 및 이를 유효성분으로 하는 골다공증 예방및 치료제.
10-0845463.
20080704.
대한민국
요로감염증의 예방및 치료를 위한 재조합 디엔에이, 플라스미드, 형질전환 미생물및 경구용 백신단백질.
10-0673872-0000.
20070118.
대한민국
Jab1을 포함하는 바이러스 감염질환치료 조성물.
10-2006-0020531.
20060306.
대한민국
요로감염증의 예방 및 치료를 위한 재조합 디엔에이, 플라스미드, 형질전환 미생물 및 경구용 백신 단백질.
US7001744.
20051111.
미국
헤리코박터 피로리 관련 질환의 예방및 치료용 백신.
10-261014-0000.
20000414.
대한민국
학술회의논문
(2017)
interferon-alpha inhibits adipocyte differentiation via JAK/STAT1 signaling pathway.
World congress on nutrition and obesity prevention source.
스페인
(2016)
IFN-alpha inhibits adipogenesisvia regulation of JAK/STAT1 signaling.
Experimental Biology 2016.
미국
(2016)
Fermented Korean red ginseng ameliorates 1-chloro-2,4-dinitrobenzene-induced atopic dermatitis vis MAPKs/NF-kb pathway in mice.
Experimental Biology 2016.
미국
(2016)
Pneumolysin induces cellular senescence in microglial cells:involvement of MAPK and NF-kb pathways.
Experimental Biology 2016.
미국
(2015)
Anti-aherosclerotic effect of sinigrin in ApoE-deficient mice.
Experimental Biology 2015.
미국
(2015)
Anti-allergic effect of ramalin from Ramalina terebrata in TNF-a-stimulated HaCaT and RBL-2H3 cells.
Experimental Biology 2015.
미국
(2015)
Pneumococcal protein PspA facilitates S. pneumoniae-induced pyroptosis.
Experimental Biology 2015.
미국
(2014)
3-Hydroxyanthranilic acid inhibits LPS-induced cytokine production through suppression of P!3k/NF-kB signaling pathways in RAW 264.7 macrophages.
대한약학회 추계학술대회.
대한민국
(2014)
Inhibition of TNF-alpha-induced adhesion molecule expression by Lobastin in mouse vascular smooth muscle cells via downregulation of p38, ERK and NF-kB signaling pathwaays.
대한약학회 추계학술대회.
대한민국
(2014)
inhibition of LPS-induced inflammatory cytokine production by KIS-712 via suppression of JNK, ERK, AP-1 and NF-kB signaling pathways in Macrophages.
대한약학회 추계학술대회.
대한민국
(2014)
In vivo immunomodulatory effect of S22-Gda.
Experimental biology 2014.
미국
(2014)
The inhibitory effect of sinigrin on the production of inflammatory mediators induced by LPS in RAW 264.7 macrophages.
Experimental Biology 2014.
미국
(2014)
Theobromine suppresses adipocyte differtiation through the MAPK pathway in 3T3-L1 preadipocytes.
Experimental Biology (미국영양학회).
미국
(2014)
anti-obese effect of ramalin in high-fat diet-induced obese mice.
Experimental Biology 2014.
미국
(2014)
In vivo immunostimulatory properties of S22 extracted Celosia argenitea Linne in C57BL/6 mice.
Experimental Biology 2014.
미국
(2014)
Ramalin suppresses adipocyte differentiation through the MAPK pathway in 3T3-L1 preadipocyte.
Experimental Biology 2015.
미국
(2014)
The apoptotic effect of ramalin on human breast cancer cells.
Experimental Biology 2014.
미국
(2013)
Anti-inflammatory activities of L-methone and Camphor isolated fro Agastache rugosa Kuntze.
대한약학추계학술대회.
대한민국
(2013)
Linalool and Linalyl acetate isolated from Agastache rugosa Kuntze inhibits the production of macrophage-derived inflammatory mediators.
대한약학회 추계학술대회.
대한민국
(2013)
The role of ikaros in adipocyte differentiation of MDI-stimulated 3T3-L1 cells.
Immunology 2013.
미국
